Why do humans still retain uric acid?

Sounds like a lot of bad things have to do with uric acid, so why do humans keep it?

In fact, a long time ago, human ancestors, like other mammals, could break down uric acid and could degrade it into allantoin, or even carbon dioxide and water, which was excreted directly from the body.

However, 15 million years ago, humans suddenly lost this ability. Since then, human uric acid levels have been, on average, four to six times higher than those of other mammals. Could this be degeneration in human evolution?

In fact, it was a clear case of natural selection. In the three populations of humans, great apes, and small apes, a change has coincided: the absence of uric acid catabolic

The population with no uric acid-degrading enzymes and high uric acid levels survived, while those with uric acid-degrading acids and even lower uric acid levels disappeared from the face of the earth forever.

      

After a lengthy study, scientists found that humans who chose to keep uric acid in their bodies acquired the latter four important categories of functions


The first function is that of raising blood pressure and lipids.

Humans use salt to maintain higher blood pressure to meet the blood pressure needs of the body to walk, run, and think in an upright position. But what if primitive humans couldn't get enough salt? That's when uric acid helped them out.

With less salt, the kidneys reduce uric acid excretion, maintaining blood pressure by elevating uric acid. And in addition to blood pressure, recent studies have shown that uric acid also stimulates fat

storage. You would think that converting more sugar into fat and storing it in the body would certainly be more conducive to surviving in a tough natural environment.

The second function of uric acid is that it stimulates human nerves.

Uric acid has a similar structure to caffeine, so it stimulates the human nerves to a certain extent, making humans more responsive and more intelligent.

And then the third function is, to enhance the immune system.

When a cell dies, the purines in its genetic material are degraded into uric acid, which is released into the body. If cells die in large numbers, the level of uric acid in the body will rise.

What do you think happens when the body's cells die in large numbers? Most likely it is to the point of danger. So this is when the elevated uric acid becomes a dangerous signal to the immune system, which stimulates the immune system to work harder.

This immune enhancement can, to some extent, prevent tumors from occurring because newly born tumor cells will be detected by the hard-working immune system and destroyed in time

Finally, the fourth function of uric acid is, antioxidant and anti-aging.

Our body produces oxygen-free radicals daily, and in excess, it can lead to various chronic diseases, and pains and also accelerate aging. And uric acid and vitamin C and vitamin

E are antioxidants that can fight against oxygen free radicals in the body.

In the long evolution of life, the acquisition of vitamin C is often lacking, so elevated uric acid can improve the antioxidant function and thus play an anti-aging and life-extending role.

The Nature of Uric Acid

At this point, you may be wondering how uric acid can be a pro-oxidant that initiates the inflammatory response that leads to fatal cardiovascular disease and gout.

But at the same time, it is an antioxidant that fights aging, tumors, and chronic diseases?


In fact, this is precisely the nature of uric acid in the body. Uric acid is like a double-edged sword:

If levels are normal, it is an antioxidant that protects us, strengthens our immune system, and fights age:

If levels are too high, it can act as a pro-oxidant, promoting oxidative stress and initiating inflammation, which can lead to a range of serious diseases.



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